Clinical Studies


Auerbach, B. D., Rodrigues, P. V., & Salvi, R. J. (2014). Central gain control in tinnitus and hyperacusis. Frontiers in neurology, 5, 206.

Cacace, A. T. et al. (2017) ‘Glutamate is down-regulated and tinnitus loudness-levels decreased following rTMS over auditory cortex of the left hemisphere: A prospective randomized single-blinded sham-controlled cross-over study.’, Hearing research. Netherlands. doi: 10.1016/j.heares.2017.10.017.

Chen YC, Li X, Liu L, Wang J, Lu CQ, Yang M, Jiao Y, Zang FC, Radziwon K, Chen GD, Sun W, Krishnan Muthaiah VP, Salvi R, Teng GJ (2015).Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network. Elife.12;4:e06576. doi: 10.7554/eLife.06576. PMID: 25962854; PMCID: PMC4426664.

Cvetkovic, Dean & Cosic, Irena. (2009). Alterations of human electroencephalographic activity caused by multiple extremely low frequency magnetic field exposures. Medical & biological engineering & computing. 47. 1063-73. 10.1007/s11517-009-0525-1.

Figueiredo RR, de Azevedo AA, Penido Nde O. (2015). Tinnitus and arterial hypertension: a systematic review. Eur Arch Otorhinolaryngol. 272(11):3089-94. doi: 10.1007/s00405-014-3277-y. Epub. PMID: 25190255.

Folmer, R. L. et al. (2015) ‘Repetitive Transcranial Magnetic Stimulation Treatment for Chronic Tinnitus: A Randomized Clinical Trial.’, JAMA otolaryngology– head & neck surgery. United States, 141(8), pp. 716–722. doi: 10.1001/jamaoto.2015.1219.

Formanek, M. et al. (2018) ‘Combined transcranial magnetic stimulation in the treatment of chronic tinnitus.’, Annals of clinical and translational neurology. United States, 5(7), pp. 857–864. doi: 10.1002/acn3.587.

Goodwin, T. (2003) Physiological and molecular effects of time-varying electromagnetic fields on human neuronal cells. Technical Paper: NASA/TP-2003-212054

Imsuwansri, T., Hoare, D. J., Phaisaltuntiwongs, W., Srisubat, A., & Snidvongs, K. (2016). Glutamate receptor antagonists for tinnitus. The Cochrane Database of Systematic Reviews, 2016(10), CD012391.

Langguth, B., Landgrebe, M., Kleinjung, T., Sand, G. P., & Hajak, G. (2011). Tinnitus and depression. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 12(7), 489–500.

Lee, C. H., & Giuliani, F. (2019). The Role of Inflammation in Depression and Fatigue. Frontiers in immunology, 10, 1696.

Lee, H. Y. et al. (2013) ‘Short term effects of repetitive transcranial magnetic stimulation in patients with catastrophic intractable tinnitus: preliminary report.’, Clinical and experimental otorhinolaryngology. Korea (South), 6(2), pp. 63–67. doi: 10.3342/ceo.2013.6.2.63.

Li, X., Xu, H., Lei, T., Yang, Y., Jing, D., Dai, S., Luo, P., & Xu, Q. (2017). A Pulsed Electromagnetic Field Protects against Glutamate-Induced Excitotoxicity by Modulating the Endocannabinoid System in HT22 Cells. Frontiers in neuroscience, 11, 42.

Lo, Y. L. et al. (2014) ‘A comparison study of repetitive transcranial magnetic stimulation for tinnitus treatment in an Asian population.’, Clinical neurology and neurosurgery. Netherlands, 119, pp. 96–99. doi: 10.1016/j.clineuro.2014.01.012.

Markov (Ed) 2017. Dosimetry in Bioelectromagnetics. CRC Press; Taylor and Francis Group.

Ozbay, I., Kahraman, C., Balikci, H. H., Kucur, C., Kahraman, N. K., Ozkaya, D. P., & Oghan, F. (2015). Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: prospective, controlled clinical study. The Journal of laryngology and otology, 129(6), 544–547.

Park, E., Kim, H., Choi, I. H., Han, H. M., Han, K., Jung, H. H., & Im, G. J. (2020). Psychiatric Distress as a Common Risk Factor for Tinnitus and Joint Pain: A National Population-Based Survey. Clinical and experimental otorhinolaryngology, 13(3), 234–240.

Piccirillo, J. F. et al. (2011) ‘Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitus.’, Archives of otolaryngology–head & neck surgery. United States, 137(3), pp. 221–228. doi: 10.1001/archoto.2011.3.

Rikk, J., Finn, K. J., Liziczai, I., Radák, Z., Bori, Z., & Ihász, F. (2013). Influence of pulsing electromagnetic field therapy on resting blood pressure in aging adults. Electromagnetic biology and medicine, 32(2), 165–172.

Roland, N. J. et al. (1993) ‘Electromagnetic stimulation as a treatment of tinnitus: a pilot study’, Clinical Otolaryngology & Allied Sciences. doi: 10.1111/j.1365-2273.1993.tb00847.x.

Ross C.L , Zhou Y, McCall C., Soker S., and Criswel,T. (2019). The Use of Pulsed Electromagnetic Field to Modulate Inflammation and Improve Tissue Regeneration: A Review. Bioelectricity..247-259.

Rossi, S. et al. (2007) ‘Effects of repetitive transcranial magnetic stimulation on chronic tinnitus: a randomised, crossover, double blind, placebo controlled study’, Journal of Neurology, Neurosurgery & Psychiatry. BMJ Publishing Group Ltd, 78(8), pp. 857–863. doi: 10.1136/jnnp.2006.105007.

Shore, S. E., Roberts, L. E., & Langguth, B. (2016). Maladaptive plasticity in tinnitus–triggers, mechanisms and treatment. Nature reviews. Neurology, 12(3), 150–160.

Stewart, GM, Wheatley‐Guy, CM, Johnson, BD, Shen, WK, Kim, C‐H. (2020). Impact of pulsed electromagnetic field therapy on vascular function and blood pressure in hypertensive individuals. J Clin Hypertens., 22: 1083– 1089.

Thomas, A. W., Graham, K., Prato, F. S., McKay, J., Forster, P. M., Moulin, D. E., & Chari, S. (2007). A randomized, double-blind, placebo-controlled clinical trial using a low-frequency magnetic field in the treatment of musculoskeletal chronic pain. Pain research & management, 12(4), 249–258.

Van Belkum, S. M., Bosker, F. J., Kortekaas, R., Beersma, D. G., & Schoevers, R. A. (2016). Treatment of depression with low-strength transcranial pulsed electromagnetic fields: A mechanistic point of view. Progress in neuro-psychopharmacology & biological psychiatry, 71, 137–143.

Vanneste, S., Song, J. J., & De Ridder, D. (2018). Thalamocortical Dysrhythmia detected by machine learning. Nature communications, 9(1), 1103.

Weiler, E. W., & Brill, K. (2005). Pulsed Magnetic-Field Therapy: A New Concept to Treat Tinnitus? The international tinnitus journal, 11(1), 58–62.

Yang, P., Ma, W., Zheng, Y., Yang, H., & Lin, H. (2015). A Systematic Review and Meta-Analysis on the Association between Hypertension and Tinnitus. International journal of hypertension, 2015, 583493.

Zhao, Y., Song, Q., Li, X., & Li, C. (2016). Neural Hyperactivity of the Central Auditory System in Response to Peripheral Damage. Neural plasticity, 2016, 2162105.

Notched Music (Cleanhearing Tinnitus App)

Eggermont, J.J., & Roberts, L.E. (2012). The neuroscience of tinnitus: understanding abnormal and normal auditory perception. Front Syst. neurosci. 6:53.

Lugli, M., Romani, R., Ponzi, S., Bacciu, S., & Parmigiani, S. (2009). The windowed sound therapy: a new empirical approach for an effective personalized treatment of tinnitus. The international tinnitus journal, 15(1), 51-61.

Okamoto, H., Stracke, H., Stoll, W., & Pantev, C. (2010). Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity. Proceedings of the National Academy of Sciences of the United States of America, 107(3), 1207-1210.

Pantev, C., Okamoto, H., & Teismann, H. (2012). Music-induced plasticity and lateral inhibition in the human auditory cortex as foundations for tonal tinnitus treatment. Frontiers in systems neuroscience, 6(June), 50.

Pantev, C., Okamoto, H., & Teismann, H. (2012). Tinnitus: the dark side of the auditory cortex plasticity. Annals of the New York Academy of Sciences, 1252(1), 253-8.

Pape, J., paraskevopoulos, E., Bruchmann, M., Wollbrink, A., Rudack, C., & Pantev, C.(2014). Playing and listening to tailor-made notched music: Cortical plasticity induced by unimodal and multimodal training in tinnitus patients. Neural Plasticity. 2014:516163.

Stein, A., Engell, A., Junghoefer, M., Wunderlich, R., Lau, P., Wollbrink, A., Rudack, C., Pantev, C.(2015). Inhibition-induced plasticity in tinnitus patients after repetitive exposure to tailor-made notched music. Clinical Neurophysiology, S1388-2457(14)00473-8.

Stein, A., Engell, A., Lau, P., Wunderlich., R., Junghoefer, M., Wollbrink, A., Bruchmann, M., Rudack, V., & Pantev, C. (2015). Enhancing inhibition-induced plasticity in tinnitus-spectral energy contrasts in tailor-made notched music matter. PLoS One. 10, e0126494.
Stein, A., Wunderlich, R., lau, P., Engell, A., Wollbrink, A., Shaykevich, A., Kuhn, J-T., Holling, H., Rudack, C., & Pantev, C., (2016). Clinical trial on tonal tinnitus with tailor-made notched music training. BMC Neurol. 16, 38.

Stracke, H., Okamoto, H., Pantev, C.(2010). Customized notched music training reduces tinnitus loudness. Communicative integrative biology, 3(3), 274-277.

Teismann, H., Okamoto, H., & Pantev, C.(2011). Short and intense tailor -made notched music training against tinnitus:the tinnitus frequency matters. PLoS One, 6(9), e24685.

Teismann, H., Wollbrick, A., Okamoto, H., Schlaug, G., Rudack, C., & Pantev, C.(2014). Combining transcranial direct current stimulation and tailor-made notched music training decrease tinnitus-related distress -a pilot study. PLoS One 9, e89904

Weisz, N.(2013). Aktuelle Trends aus der neurowissenschaftlichen Tinnitus-Forschung und deren klinische Implikationen. Tinnitus-Forum, 17(1), 18-21.

Weisz, N., & Langguth, B.(2010). [Cortical plasticity and changes in tinnitus: treatment options]. HNO, 58(10), 983-9

Willson, E., Schlaug, G., & Pantev, C.(2010). Listening to filtered music as a treatment option for tinnitus: A review. Music perception, 27(4), 327-330.

Wunderlich, R., Lau, P., Stein, A., Engell, A., Wollbrink, A., Rudack, C., & Pantev, C(2015). Impact of spectral Notch width on Neurophysiological Plasticity and Clinical Effectiveness of the Tailor-made Notched Music Training. PLoS One 10, e0138595.